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ANDI News

The Nautilus Diving Center and ANDI Training Academy is one of Baja’s premier diving facilities. October 2010 marks the Grand Opening. Although the facility has been operating privately for a number of years, it will open as a full service diving operation this fall.

This dive center has been built on the premise of providing customers with all the tools to safely enjoy diving regardless of training level. Team Nautilus strives to build relationships with their clients that result in well-trained divers who look to continuously expand their knowledge of the sport.

The Nautilus Diving Center and ANDI offer their divers top quality education along with the support and service required to keep them diving. In addition to training, the Center also offers local tours and charters for divers of every certification level.

Nautilus Dive Center specializes in small groups and VIP service, but can network with other operators to coordinate large group activities.

As the facility was developing, one of the primary goals was to create the necessary logistics to smoothly run classes that range from entry level diving to full technical training.

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The dive center’s one of a kind pool provides extremely controlled conditions in which to learn new skills, try out new equipment, and practice different gear configurations before entering open water. The heated pool has a four-foot level, in which divers can practice shallow water skills and a 15 foot deep area. The deep water end of the pool is ideal for training closed circuit rebreather divers.

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Each diver’s safety starts with the quality of the air they are breathing. The Nautilus Diving Center completed their gas distribution/blending station in the spring of 2010. The gas is sampled every quarter and complies with the highest standards of gas purity in the world.

They offer oxygen compatible air fills; enriched air nitrox, tri-mix, and 3000 psi oxygen fills for rebreathers.

The system includes:

Poseidon HP compressor (4) filter stacks (8) cascade cylinders

(7) oxygen cylinders (3) helium cylinders (2) Haskel booster pumps

LP drive compressor blending panel oxygen/helium analyzers

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Diver safety also depends on quality gear that is maintained by qualified personnel. The Nautilus Diving Center offers customers top end dive gear in both their rental and resale departments. The Workshop provides the proper workspace and equipment to perform equipment repairs, annual maintenance, oxygen cleaning, and also serves as a classroom for teaching ANDI technician programs.

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The Nautilus Diving Center’s classrooms offer a comfortable workspace for divers to learn academics and practice hands-on skills. The indoor air-conditioned classroom has wireless Internet access, a multimedia projector, and student refreshment area.

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Outdoor amenities include two palapas that provide shade for outside activities, (2) outside showers, (4) rinse tanks, and gear drying racks.

The primary palapa covers the gear lockers and student work areas. These spaces are setup for each diver to have a private workspace to assemble their gear and safely store it overnight. Each workstation is equipped with overhead lights…just in case a class goes late….

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Nautilus Diving Center’s primary boat is a 21-foot Carolina Skiff that has a 90 hp Mercury motor, a 15 hp kicker motor, and a 30-gallon fuel supply. It is equipped with a sun canopy, life jackets, first aid kit, oxygen supply, marine radio, GPS, gear storage hatches, and equipment lift crane. The Carolina Skiff is an excellent dive platform with plenty of deck space and seated platforms to suit up technical divers.

Other boats are also available through our network of operators.

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Nautilus Diving Center and ANDI Training Academy offers diver education from entry level to advanced technical applications. In-house instruction currently specializes in the following programs.

SafeAir Sport Diver Complete SafeAir User

Technical SafeAir Diver Technical Tri-mix Diver

Introduction to Rebreathers Level 2 Nautilus Rebreather

Technical Rebreather Diver Technical Trimix Rebreather

In 2011, The Nautilus Diving Center staff will also be offering certified service technician program, gas blender program, and instructor training programs.

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Retail Sales/Mail Order Boat Charter/Tours

Recreational & Technical Gear Rental Cylinder Rental

Rebreather Supplies ANDI SafeAir/OCA

Enriched Air Nitrox Tri-mix

Equipment Servicing Oxygen Cleaning

Cylinder Tumbling

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Cabo San Lucas offers an unique experience for divers. It marks the point where the Pacific Ocean and the Sea of Cortez meet. Water temperatures fluctuate with the seasons, exchanging tropical marine life for larger pacific animals. Water temperature varies between the mid 60s to the high 80s depending on the time of year. Visibility ranges from 20-80 feet.

The nutrient rich waters provide an eco system for a vast array of marine life.

Regional dive sites are home to giant mantas, hammerhead sharks, humpback whales, whale sharks, sea lions, turtles, groupers, snappers, amber jacks, tuna, barracuda, scorpion fish, puffer fish, lobsters, sea horses, eels, rays, goat fish, needle fish, and a variety of other animals.

The region’s dive sites are split into four different areas.

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Offers excellent opotunities for dive training and short excursions. The bay is exceptionally calm with little or no current. Depth ranges from 15 feet to the virtual abyss of the Cabo San Lucas Canyon. Sites are less than a ten minute boat ride from the Marina.

Dive sites include the North Wall, Pelican Rock, Neptune’s Finger, Lands End, Mid Wall, and the Sand Falls.

This area was established as a National Marine Park in 1973.

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The Corridor separates Cabo San Lucas from San Jose del Cabo and is home to several sites that offer a different experience from the sloping terrain of the Canyon. These sites are 15-30 minutes from the Marina and include Whales Head, Santa Maria, Chilleno, and the Blow Hole.

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Gordo Banks is an advanced dive site about 1.5 hours away by boat. It is located 5 miles off shore. The seamount starts at about 100 feet with an the average depth of 130 feet. This is where the big marine life can be seen.

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Cabo Pulmo was established as a Marine Park in 1995. It is one of only three living reefs in North America and the only one in the Sea of Cortez. The park consists of multiple fingers of hard coral that span across the park’s boundaries. Average depth is 50-60 feet. These dive sites are approximately 2 hours away by car with a short boat ride.

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Cabo San Lucas is an internationally recognized tourist destination with daily cruise ship activity. It is in one of the fastest growing areas in Mexico. The area between San Jose del Cabo and Cabo San Lucas has nearly 20 miles of sandy beaches and beachfront resorts. The region offers something for the whole family to enjoy. Divers and non-divers alike can enjoy this desert paradise.

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Commercial flights are readily available from all parts of the United States and Mexico. Shuttle and Taxi services bring travelers from the airport in San Jose del Cabo to Cabo San Lucas. Travel time is about 45 minutes.

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Hotel accommodations cater to all levels of taste and budget. They span from lavish and luxurious to modest and practical. Hotels may be located on the beach or in the downtown area. There are several properties near the dive center that run $40-$60/night with well appoint air-conditioned rooms, pools, and on site restaurants.

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Cabo San Lucas offers dining that tempts every traveler’s palate and wallet. Local establishments provide excellent bargains that are sure to satisfy, while the tourist walk provides excellent cuisine, intriguing atmospheres, and entertainment that is sure to stimulate the appetite and senses. It seems travelers are never more than a few feet from a cold beverage or tasty meal.

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Scuba Diving Deep Sea Fishing Cabo Dolphin Experience

Kayaking Snorkeling Golf Courses

Glass Bottom Boat Tours Para Sailing Party Cruises

ATV/Baja Racer Tours Horseback Riding Beach Activities

Zip Line Tours Jeep Desert Tours Whale Watching

Puerto Paraiso Mall Marina Boardwalk Local Arts and Crafts

Cultural Centers Exciting Nightlife Art Galleries

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Reductions of both ARG1 and NOS2 expression via PDE5 inhibition should affect both suppressive pathways, resulting in less MDSC-mediated immunosuppression and, therefore, enhanced antigen-specific T cell proliferation. To test this hypothesis, tumor-derived CD11b+ MDSCs were isolated from C26GM-bearing BALB/c mice. MDSC suppressive activity was determined by admixing MDSCs with CFSE-labeled HA-specific CD8+ (clone 4) or CD4+ (6.5) T cells pulsed with their relevant peptide in the presence or absence of sildenafil (Fig. 7, A and B). Although the addition of tumor-derived MDSCs significantly impaired antigen-specific T cell proliferation as demonstrated by the low percentage of CFSElow clonotypic T cells, sildenafil almost completely restored both CD4+ and CD8+ responsiveness of these antigen-specific T cells. The absence of sildenafil-mediated enhancement in T cell function in the groups lacking CD11b+ cells underscores the targeted role of sildenafil on the MDSC population. Because in a Th1 cell�prone environment MDSC suppression is only NOS2 dependent (34), we examined the role of PDE5 in MDSCs in a C57BL/6 background where NOS2�/� mice are also available. CD11b+ MDSCs were isolated from either C57BL/6-NOS2+/+ or B16GM-bearing C57BL/6-NOS2�/� B16GM melanoma-bearing mice. A suppression assay was performed by stimulating OVA-specific CD4+ T cells with the relevant peptide in the presence or absence of MDSCs obtained from either NOS2+/+ or NOS2�/� tumor-bearing mice (Fig. 7 C). Although the addition of C57BL/6-NOS2+/+ MDSCs induced considerable T cell suppression, no suppression was observed with MDSCs from NOS2�/� mice. Furthermore, although PDE5 inhibition reversed MDSC suppression in NOS2+/+ mice, sildenafil failed to augment T cell responsiveness in the NOS2�/�-derived MDSC suppression assay. 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